Immunological studies on Histoplasma capsulatum

Immunological studies on Histoplasma capsulatum.

Alveolar macrophages freshly harvested from normal and immunized rabbits were parasitized with yeast cells and protoplasts of Histoplasma capsulatum. Macrophages obtained from either normal or sensitized rabbits failed to phagocytize protoplasts, whereas, the yeast cells were actively ingested. There was no detectable intracellular killing by macrophages. A serological similarity was found betw...

Cultural Studies on the Yeastlike Phase of Histoplasma capsulatum Darling.

Biochemical and Immunological Properties of Histoplasma Capsulatum No. 650 *

The morphological identification of the causative agent of "histoplasmosis" made possible the recognition of the disease and disclosed its wide distribution.t However, it is only by a more complete understanding of the biochemistry and immunology of this organism that its pathological action may be explained. Only scattered dbservations have *been reported3 6, 8, 9, 15 and the present investiga...

Histoplasma capsulatum Endocarditis

Infective endocarditis is an uncommon manifestation of infection with Histoplasma capsulatum. The diagnosis is frequently missed, and outcomes historically have been poor. We present 14 cases of Histoplasma endocarditis seen in the last decade at medical centers throughout the United States. All patients were men, and 10 of the 14 had an infected prosthetic aortic valve. One patient had an infe...

Intracellular Behavior of Histoplasma Capsulatum.

Howard, Dexter H. (University of California, Los Angeles). Intracellular behavior of Histoplasma capsulatum. J. Bacteriol. 87:33-38. 1964.-The tinctorial characteristics and intracellular generation time of Histoplasma capsulatum within mouse histiocytes maintained in tissue culture were studied. The appearance of viable and nonviable cells of H. capsulatum was observed after staining with the ...